Histogram-Based Analysis of Low- and High-Grade Glioma and Its Surrounding Edema Using Arterial Spin Labeling Magnetic Resonance Imaging

A glioma is a type of intra-axial brain tumor originating from the glial cells. Making up about one-third all tumors, timely diagnosis alongside correct grading and subsequent therapy planning crucial. Magnetic Resonance Imaging an established method for tumors. Arterial Spin Labeling (ASL) Perfusion allows non-contrast enhanced visualization hyper- or hypoperfusion. Commonly, cell swelling occurs around that causes edema, which subsequently puts healthy tissue at risk by potentially reducing regional perfusion. The patient collective in this study consists 495 patients (501 scans) with histopathologically confirmed grade II-IV diffuse gliomas. aim was to evaluate potential histogram analysis ASL data find biomarkers pathological diagnosis, grading, MGMT, mutation status tumors as well tumor-surrounding edema. showed statistically significant results but not MGMT mutation. differentiation between edema highly yet did show differences perfusion on contralateral hemisphere.